CZRC Catalog ID: |
CZ1254 |
Availability: |
Embryos/Adults |
Genotype: |
apcihb347/+
|
Affected Gene: |
apc (1)
|
Genotyping: |
unspecified |
Background: |
AB |
Affectedgeneurl: |
unspecified |
Linetype: |
Mutant |
Previous Names: |
cb965 (1), im:7150932, im:7152872 |
Background: |
AB |
Affectedgeneurl: |
unspecified |
Linetype: |
Mutant |
Previous Names: |
cb965 (1), im:7150932, im:7152872 |
Note:
Predicted to have beta-catenin binding activity; microtubule binding activity; and protein kinase regulator activity. Involved in several processes, including animal organ development; chordate embryonic development; and embryonic pectoral fin morphogenesis. Predicted to localize to several cellular components, including the beta-catenin destruction complex; intracellular non-membrane-bounded organelle; and lateral plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including adenoma; carcinoma (multiple); endometrial cancer (multiple); familial adenomatous polyposis 1; and medulloblastoma. Orthologous to human APC (APC regulator of WNT signaling pathway)
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